George Kambosos Jr will fight a new opponent on his March 22 homecoming show in Sydney after Daud Yordan had to be pulled from the contest on medical grounds.

The show, which takes place at the Qudos Bank Arena in Australia this Saturday, will now be headlined by Kambosos Jr's clash against compatriot Jake Wyllie.

Veteran Yordan (43-4, 1NC, 31 KOs) was ruled out of the bout after failing a medical following a trip to the hospital in his home country of Indonesia.

Wyllie, 24, is promoted by No Limits Boxing and is the current Australian junior-welterweight champion.

The show, which also features two women's world title fights including Skye Nicolson's defence of her WBC 126-pound strap vs. Tiara Brown, will be shown worldwide on DAZN.

“This is what dreams are made of. I'd already arranged tickets to come watch on Saturday and now I'm fighting in the main event,” said the Australian Super-Lightweight Champion, Wyllie (16-1-0, 15 KOs).

“This is the opportunity of a lifetime and I'm ready to take it with both hands. George has boxed at the highest level in the sport but I'm young, ambitious, and ready to put it all on the line in Sydney on Saturday. Expect fireworks! Jake ‘The Machine’ Wyllie is coming.”

Kambosos Jr (21-3, 10 KOs) was relishing the chance to take on a very popular fighter in Yordan, set to have thousands of his countrymen in town for the fight following Thursday's football World Cup qualifier between Australia and Indonesia.

Kambosos Jr added: “Boxing is unpredictable and it is very unfortunate to have Daud Yordan medically pull out, five days before the event, but the Ferocious show goes on because there is no show without me.

“Victory is the only thing on my mind, no matter what, and it sets up my 140-pound World Title shot next. I want to give a good local Aussie kid a shot. Jake Wyllie, 16-1, 15 KOs, stands out.

"He is the current Australian 140 National Champion, the only one that hasn't been disrespectful for a payday, and I like how he has gone about his business in the boxing world.

“So, I'm giving Jake the ‘Rocky’ shot! The opportunity, but that’s where it ends. This is not a Rocky movie, don't get it twisted, there is no happy ending. A Ferocious statement is what you’ll see on Saturday night. Victory by any means.”