Spence, coming off a devastating ninth-round knockout loss to Terence Crawford in July 2023, is scheduled to face Tim Tszyu (27-3, 18 KOs) on July 26 at a yet-to-be-determined site in Australia.

Charlo doesn't like the opponent nor the location for Spence (28-1, 22 KOs) in Tszyu's home country.

"I think Tim Tszyu is going to win that fight," Charlo said on The Last Stand Podcast.

Tszyu, former WBO junior middleweight titleholder, hasn't had much success in recent years. He's .500 in his last six, losing three of four in 2024 and '25 — including knockout setbacks against Bakhram Murtazaliev and Sebastian Fundora — before bouncing back to win two straight against unbeaten but unheralded opposition.

Spence, meanwhile, has taken plenty of time to rejuvenate away from the public eye. He has also moved on from longtime trainer Derrick James, deciding to work with Ronnie Shields.

All of this plays a factor for Charlo when breaking their fight down.

For years, the pair worked in tandem under James' watchful guidance, and the former Ring and undisputed 154-pound champion is closer than most. While it may seem like he's taking a shot at Spence given their fractured relationship, he counters he's looking at things with an unbiased lens.

"When I'm going by the styles of fights and being realistic, he's going over there to Australia, the odds ain't in his hands," Charlo said. "Errol's going to be coming in and don't really move his head. Tim Tszyu throws haymakers, all of his shots are. I see Tim Tszyu winning this fight, plain and simple."