The 37-year-old will make her second championship defense of 2026 when facing Germany's Cheyenne Hanson (17-2, 13 KOs) in the first of a double main event as MVPW-03 gets underway Saturday in El Paso, Texas.

Having outpointed unbeaten American Reina Tellez on January 3 in Puerto Rico, the savvy southpaw makes her 54th professional appearance against another foe who grew up watching her dominate as she floated between several weight divisions.

During Thursday's final press conference, the Ring and unified featherweight titleholder welcomed the challenge of an opponent with nothing to lose.

"She's a young, hungry fighter. This is a big platform for her and great opportunity to show the world who Cheyenne is," Serrano said. 

"I never look past any opponent and that's why we trained really hard for Cheyenne, working on good stuff. Hard punches and we know Cheyenne is a heavy hitter — so am I, but I invite that. I love that."

Hanson made her pro debut on September 8 2018, by which time Serrano was already a five-division champion and later that night, made it six by sweeping aside Yamila Reynoso for the WBO 140-pound title on the Danny Garcia-Shawn Porter undercard in Brooklyn, New York.

The Augsburg native, 28, doesn’t seem overawed by the challenge in her first appearance outside Europe. 

"I want to be in the ring with the best, that's why I'm here. I agree [with Amanda], it's going to be a great fight. I'm a heavy hitter, got an aggressive fighting style, but so does she. I expect a really hard, entertaining fight and can't wait for it to happen. I always wanted to fight Amanda, said it in interviews years ago and now I'm here."

Hanson will be facing a considerable step-up in quality, having only beaten five opponents with positive win-loss records in her career to this point. Serrano (48-4-1, 31 KOs) isn't as sharp as she was, but that hasn't deterred her from chasing Christy Martin's knockout record. 

She has scored just one stoppage victory (Stevie Morgan, July 2024) in her last 12 bouts dating back to March 2019. 

The Ring's No. 6-rated pound-for-pound boxer needs one to level and two to surpass the 57-year-old promoter and matchmaker, who retired in 2012 after consecutive defeats and was inducted into the Hall of Fame eight years later.

"The goal is definitely to get that Christy Martin record, so if it comes this year, then we’ll think about retiring. But until that happens, I love making history, breaking records. That's the goal."