Oscar De La Hoya knows all too well about the danger Manny Pacquiao presents.

After all, Pacquiao made his United States debut and coming-out party on a De La Hoya undercard in 2001 and went on to beat the Golden Boy into retirement with a white-hot, one-sided stoppage win in 2008. Pacquiao was days away from turning 30 at the time and operating at the peak of his powers as a pound-for-pound kingpin.

Pacquiao is still going at it 17 years later, and he'll be coming back at 46 from a four-year retirement Saturday to face WBC welterweight champion Mario Barrios at MGM Grand in Las Vegas.

Their championship contest tops a busy Premier Boxing Champions bill with two world title fights, budding contenders and returning former titleholders all featuring on another busy night of boxing to cap Prime Video's coverage ($79.95 PPV) in the fight capital.

Although Pacquiao (62-8-2, 39 KOs) is a near minus-370 betting underdog, many notable figures around the industry believe the cherry-picked Barrios (29-2-1, 18 KOs) is beatable.

"I have Pacquiao winning because of his footwork — those calves that he has are incredible and amazing," De La Hoya told reporters.

"When he jumps on his toes and confuses you and throws those punches from different angles, he doesn't get tired. I don't care if he's 50,000 years old, he's not going to get tired. He's a machine. I think the workload is going to be too much for Barrios."

Barrios is having none of it, having promised a rude role reversal in retiring the "Mexecutioner" like he did to De La Hoya.

"El Azteca" says his timing will beat Pacquiao's speed.